Slimiser treatment in a medical practice

French Innovation · CE Medical Device

Reduce localised fat deposits and firm tissue.

Slimiser uses convergent ultrasound to reshape your body — without surgery, without pain, and without any downtime.

− 5 cm Up to 5 cm waist reduction
0 pain-free
1 – 2 sessions generally needed
0 of patients notice firmer skin in the treated area
National Innovation Award winner Technology based on research with CNRS scientists Patented technology CE medical device Made in France IMCAS 2024 Selection National Innovation Award winner Technology based on research with CNRS scientists Patented technology CE medical device Made in France IMCAS 2024 Selection

Recognition

An award-winning French medical technology.

National Innovation Award winner

Slimiser is the winner of the National Innovation Competition of the French Ministry of Research.

IMCAS 2024 Selection

Selected by IMCAS, one of the world's leading congresses in aesthetic and anti-ageing medicine.

CE Medical Device — ISO 13485 Certified

Slimiser, designed and manufactured in France by Laboratoires Synthebio — certified ISO 13485 for medical device quality management — has received CE medical device marking, reflecting compliance with applicable European safety and performance requirements.

Patented technology developed with CNRS experts

Developed through research by Laboratoires Synthebio with experts from the CNRS and the École Normale Supérieure, Slimiser's convergent ultrasound technology is protected by several international patents.

Patient Results

Visible, measurable results.

Results may vary between individuals and treated tissues.

Clinical Study

Results observed during the clinical study

Clinical study day 0
Day 0
Clinical study after treatment
After

Abdomen · Clinical study · D+21 · 1 session

Clinical study day 0
Day 0
Clinical study after treatment
After

Abdomen · Clinical study · D+28 · 1 session

Medical practice

Results observed in medical practices and aesthetic medicine clinics

Before treatment
Before
After treatment
After

Treatment in medical practice · 2 sessions

Before treatment
Before
After treatment
After

Treatment in medical practice · 1 session

Before treatment
Before
After treatment
After

Treatment in medical practice · 1 session

Before treatment
Before
After treatment
After

Treatment in medical practice · D+28

Objective Measurements

Change in abdominal fat measured over time.

The anonymised Tanita report shows a progressive decrease in segmental trunk fat after treatment, with follow-up at two and then four weeks.

Data presented for illustrative purposes. Results may vary between patients.

06/05: 45.8%17/05: 30.9%28/05: 27.5%

Clinical Study

A clinical study confirming tolerability, absence of side effects and efficacy.

Clinical study conducted in France by an independent laboratory under a protocol registered with the ANSM.

0No pain reported
0Significant side effect
0Firmer abdomen
0Reduced cellulite
0Waist circumference reduction observed
0Up to 5 cm waist reduction
0Flatter stomach
0Satisfaction rate
EffectiveSafePain-freeLong-lastingFastNo downtimeSkin firming EffectiveSafePain-freeLong-lastingFastNo downtimeSkin firming

How it works

A revolutionary technology.

The handpiece draws in the skin and fat for a few seconds. The ultrasonic waves converge within the adipose tissue, concentrating mechanical energy that repeatedly compresses and stretches fat cells, disrupting their membranes.

Adipocytes can increase their fat storage volume up to 100 times, or even more in cases of extreme obesity. They are created during childhood and adolescence. Under normal circumstances, the body does not produce new ones in adulthood. Destroyed adipocytes are therefore not regenerated — there is no longer a fat storage depot.

Simultaneously with the emission of convergent ultrasound, electrodes stimulate superficial lymphatic and blood circulation to accelerate the drainage of released fat, eliminated through natural pathways.

Science

From human explants to biological measurements.

Adipocyte histology

Sections of fatty tissue taken from human explants after treatment show membrane rupture in adipocytes after 3 minutes of treatment.

Human explant — control specimen
Human explant — control specimen
Human explant after treatment
Human explant after 3 min. of treatment

Increase in biological markers post-treatment

In human explants, the increase in triglycerides, fatty acids and glycerol in the culture medium after treatment indicates measurable lipid release from adipocytes, consistent with their progressive disruption by convergent ultrasound.

Measurements on treated vs untreated control human explants.

Triglycerides0
Free fatty acids0
Glycerol0

Bars represent relative values between molecules. Free fatty acids: maximum observed value.

Patient testimonial

Slimiser love handle treatment

«It works really well!»

«I lost 3 cm off my waist and I can see a real benefit on my stomach. I could hug you!»

Karine, 26 — Île-de-France
5 days after one Slimiser treatment

Continuous innovation

AI-powered body sculpting.

Arm and knee treatments

2024

New patent filing

Enhanced protection of integrated technologies.

2025

On-board A.I.

The integrated Artificial Intelligence module analyses tissue and automatically adjusts various parameters to deliver a personalised treatment. The A.I. optimises results and ensures consistency, while extending the range of Body Mass Index (BMI) values that can be treated.

2026

New handpieces

Taking on board the requests of many patients, Laboratoires Synthebio have created new handpieces that now extend treatable areas to the arms, knees, calves, back, etc.

Press

Featured in the national, beauty and health press.

No article has been funded by Synthebio. Most journalists tested or witnessed patient results first-hand.

Medical media

A technology explained by doctors.

Pilot centre

A technology already in use in medical practice.

Dr Brigitte Desporte

Dr Brigitte Desporte: director of Senfina Clinic, the Slimiser pilot centre in Paris 17 — Neuilly-sur-Seine.

«What convinced me about the Slimiser: visible results, improvement in skin tone and a completely pain-free treatment.»
Dr Desporte performing a Slimiser treatment

FAQ

Frequently asked questions

How many sessions are needed?

The number of sessions required varies depending on body type and tissue. Generally, one or two sessions are sufficient. Additional drainage sessions using the Slimiser's electrostimulation function can be carried out once or twice a week during the following month.

Can multiple areas be treated in one session?

Yes. Some patients treat both the abdomen and thighs in the same session, for example.

Which areas can be treated?

Abdomen, love handles, hips, inner thighs, saddlebags, banana roll under the buttocks, arms, knees, calves, bat wings and chest fat in men.

How does tissue respond once fat has been eliminated?

Convergent ultrasound enhances the recognised dermotensive effect of ultrasound. The tissue tightens thanks to the destruction of adipocytes across a significant thickness, which causes tissue retraction, accelerated by electrostimulation of the microcirculatory system. 90% of patients in the clinical study judged that the treatment had tightened their skin, and 80% noticed a reduction in cellulite.

Can men benefit from Slimiser treatment?

Although fat deposits tend to be distributed differently in men, Slimiser treatment — painless and fast — is perfectly suited to men. It should be noted that Slimiser treats only subcutaneous fat (between the skin and muscles), not visceral fat.

Are there any contraindications?

Yes, including but not limited to: pregnancy, breastfeeding, haemophilia or clotting disorders, certain medications. The protocol begins with a medical consultation.

Are results guaranteed?

As with any medical treatment, every patient is unique. Results depend on several factors, including individual physiology, the thickness, location, origin and nature of adipose tissue (more or less fibrous), and how long the fat deposits have been present. A prior medical consultation therefore helps determine whether Slimiser treatment is appropriate and how to optimise results.

Is the treatment permanent?

Adipocytes form during childhood and adolescence. Destroyed adipocytes will no longer store fat. However, a very unbalanced diet, high in lipid and carbohydrate calories, can trigger the transformation of stem cells into new adipocytes, and remaining adipocytes that have not been destroyed will continue to store fat. A further treatment may then be indicated.

What are the risks?

No significant local or systemic adverse effect was observed in the clinical study, when used according to the protocol and in the absence of contraindications.

Is Slimiser equivalent to liposuction?

No: results obtained by liposuction are generally superior, especially in cases of significant excess fat. However, liposuction is a surgical procedure performed under general anaesthesia, with a heavy recovery period (pain, bruising, immobilisation…) and carries risks (nerve damage, haemorrhage, various complications).

Is the treatment reimbursed?

Slimiser treatment is not reimbursed by health insurance. Fees are set freely by practitioners and vary depending on the areas and surfaces treated. At the preliminary consultation, if you are eligible for treatment, the practitioner will provide a quote based on the areas you have discussed together.

Are GLP-1 treatments (Ozempic, Wegovy etc.) and Slimiser complementary?

Yes. GLP-1 treatments can support overall weight loss under medical supervision, primarily by acting on appetite and satiety. Slimiser addresses a different need: targeting localised areas where subcutaneous fat or tissue laxity may persist despite weight loss.

After significant weight loss, certain areas can remain difficult to reshape — abdomen, love handles, thighs, arms or knees. Slimiser can then be considered as a complementary treatment to improve body contour, firm tissue and target specific areas, without surgery and without any interruption to daily activity.

After weight loss with GLP-1, can Slimiser help reshape the body?

Yes. GLP-1 treatments (Ozempic, Wegovy etc.) can lead to significant weight loss, often around 10 to 15% of body weight depending on the patient and treatment. However, this weight loss is global: it does not always target the areas where localised fat deposits persist.

Slimiser can then be considered as a complementary treatment, once weight has stabilised, to address resistant areas — abdomen, love handles, thighs, arms, knees or back — and contribute to tissue firming (arms, thighs, abdomen...). Treatment should always be preceded by a medical consultation to verify the indication and any possible contraindications.

I am a doctor — how can I offer Slimiser treatment?

Laboratoires Synthebio were founded by and with doctors who have worked in private practice, fully aware of the financial pressures involved. We offer arrangements that allow you to equip your centre with no upfront capital investment, thanks to our partnership with a financing organisation*.

This enables our partner practitioners to offer Slimiser treatment to their patients without impacting their cash flow.

Fill in the professional form below or contact us.

Patients

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Area(s) to treat

Healthcare professionals

Doctor or head of an aesthetic medical centre?

For further information, contact Laboratoires Synthebio at +33 (0)7 49 00 34 91 or by email: info [at] synthebio.com, or by filling in and submitting the form below:

For further information, contact Laboratoires Synthebio at +33 (0)7 49 00 34 91 or by email: info [at] synthebio.com